InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACADM

Summary

InnateDB Gene

IDBG-99766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACADM

Gene Name

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Synonyms

ACAD1; MCAD; MCADH

Species

Homo sapiens

Ensembl Gene

ENSG00000117054

Encoded Proteins

IDBP-99768

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-99770

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-385919

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-597933

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-603797

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-592088

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-592926

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-595571

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-592182

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-590833

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

IDBP-602142

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:75724347-75787575

Strand

Forward strand

Band

p31.1

Transcripts

ENST00000370841	ENSP00000359878
ENST00000370834	ENSP00000359871
ENST00000420607	ENSP00000409612
ENST00000473018
ENST00000481374
ENST00000525881
ENST00000526129	ENSP00000434092
ENST00000526196	ENSP00000431953
ENST00000534146
ENST00000532509	ENSP00000432522
ENST00000530953	ENSP00000431372
ENST00000534334	ENSP00000435584
ENST00000525808	ENSP00000434823
ENST00000529059
ENST00000526930
ENST00000532207
ENST00000528016	ENSP00000434284
ENST00000541113	ENSP00000442324

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0070991	medium-chain-acyl-CoA dehydrogenase activity

Biological Process

GO:0001889	liver development
GO:0005978	glycogen biosynthetic process
GO:0006082	organic acid metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006635	fatty acid beta-oxidation
GO:0007507	heart development
GO:0008152	metabolic process
GO:0009409	response to cold
GO:0009437	carnitine metabolic process
GO:0009791	post-embryonic development
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594	response to starvation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0051791	medium-chain fatty acid metabolic process
GO:0051793	medium-chain fatty acid catabolic process
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process