InnateDB Protein
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IDBP-386072.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TIAL1
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Protein Name
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TIA1 cytotoxic granule-associated RNA binding protein-like 1
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Synonyms
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TCBP; TIAR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000394902
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InnateDB Gene
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IDBG-91185 (TIAL1)
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Protein Structure
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Function |
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
62
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
15
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR003954
RNA recognition motif domain, eukaryote
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
SM00361
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TIGRFAMs |
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Modification |
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SwissProt |
Q01085
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PhosphoSite |
PhosphoSite-Q01085
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TrEMBL |
Q2TSD2
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UniProt Splice Variant |
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Entrez Gene |
7073
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UniGene |
Hs.501203
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RefSeq |
NP_003243
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HUGO |
HGNC:11804
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OMIM |
603413
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CCDS |
CCDS7613
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HPRD |
04563
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IMGT |
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EMBL |
AC012468
AK290695
AK290984
AY633610
M96954
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GenPept |
AAA36384
AAV33303
BAF83384
BAF83673
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