InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLCN2

Summary

InnateDB Protein

IDBP-386154.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLCN2

Protein Name

chloride channel 2

Synonyms

CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11; EGI3; EGMA; EJM6; EJM8; LKPAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000391928

InnateDB Gene

IDBG-68081 (CLCN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006810	transport
GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0034707	chloride channel complex

Protein Structure and Domains

PDB ID

InterPro

IPR001807 Chloride channel, voltage gated
IPR002244 Chloride channel ClC-2
IPR014743 Chloride channel, core

PFAM

PF00654

PRINTS

PR00762
PR01113

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51788

PhosphoSite

PhosphoSite-P51788

TrEMBL

UniProt Splice Variant

Entrez Gene

1181

UniGene

Hs.436847

RefSeq

NP_001164560

HUGO

HGNC:2020

OMIM

600570

CCDS

CCDS54692

HPRD

02782

IMGT

EMBL

AC078797 AF026004 AK298952 AK302759 BC021578 BC072004 S77770

GenPept

AAB34722 AAB88807 AAH21578 AAH72004 BAG61051 BAG63970