Version 5.4
Homo sapiens Gene: CLCN2
Summary
InnateDB Gene IDBG-68081.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCN2
Gene Name chloride channel, voltage-sensitive 2
Synonyms CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11; EGI3; EGMA; EJM6; EJM8; LKPAT
Species Homo sapiens
Ensembl Gene ENSG00000114859
Encoded Proteins
IDBP-68083
chloride channel 2
IDBP-68085
chloride channel 2
IDBP-386152
chloride channel 2
IDBP-386154
chloride channel 2
IDBP-386155
chloride channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:184346185-184361651
Strand Reverse strand
Band q27.1
Transcripts
ENST00000265593 ENSP00000265593
ENST00000344937 ENSP00000345056
ENST00000430397 ENSP00000396231
ENST00000457512 ENSP00000391928
ENST00000434054 ENSP00000400425
ENST00000491162
ENST00000485667
ENST00000475279
ENST00000465231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:0060041 retina development in camera-type eye
GO:0060689 cell differentiation involved in salivary gland development
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022843
View Gene Order
ENSBTAG00000012284
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436847
RefSeq NM_001171087 NM_001171088 NM_001171089 NM_004366 XM_006713490
HUGO
OMIM
CCDS CCDS3263 CCDS54690 CCDS54691 CCDS54692
HPRD 02782
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca