Version 5.4
Homo sapiens Protein: CLCN2
Summary
InnateDB Protein IDBP-386155.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCN2
Protein Name chloride channel 2
Synonyms CIC-2; clC-2; CLC2; ECA2; ECA3; EGI11; EGI3; EGMA; EJM6; EJM8; LKPAT;
Species Homo sapiens
Ensembl Protein ENSP00000400425
InnateDB Gene IDBG-68081 (CLCN2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
Protein Structure and Domains
PDB ID
InterPro IPR000644 CBS domain
IPR001807 Chloride channel, voltage gated
IPR002244 Chloride channel ClC-2
IPR014743 Chloride channel, core
PFAM PF00571
PF00654
PRINTS PR00762
PR01113
PIRSF
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51788
PhosphoSite PhosphoSite-P51788
TrEMBL
UniProt Splice Variant
Entrez Gene 1181
UniGene Hs.436847
RefSeq NP_001164559
HUGO HGNC:2020
OMIM 600570
CCDS CCDS54690
HPRD 02782
IMGT
EMBL AC078797 AF026004 AK298952 AK302759 BC021578 BC072004 S77770
GenPept AAB34722 AAB88807 AAH21578 AAH72004 BAG61051 BAG63970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca