InnateDB Protein
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IDBP-386189.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHRD
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Protein Name
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chordin
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392794
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InnateDB Gene
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IDBG-68217 (CHRD)
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Protein Structure
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Function |
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed at the highest level in liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001501
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skeletal system development
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GO:0002053
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positive regulation of mesenchymal cell proliferation
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GO:0021919
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BMP signaling pathway involved in spinal cord dorsal/ventral patterning
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GO:0030336
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negative regulation of cell migration
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GO:0030514
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negative regulation of BMP signaling pathway
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GO:0033504
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floor plate development
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GO:0045668
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negative regulation of osteoblast differentiation
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GO:0045785
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positive regulation of cell adhesion
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Cellular Component |
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PDB ID |
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InterPro |
IPR001007
von Willebrand factor, type C
IPR010895
CHRD
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PFAM |
PF00093
PF07452
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PRINTS |
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PIRSF |
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SMART |
SM00214
SM00754
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2X0
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PhosphoSite |
PhosphoSite-Q9H2X0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8646
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UniGene |
Hs.166186
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RefSeq |
XP_005247908
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HUGO |
HGNC:1949
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OMIM |
603475
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CCDS |
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HPRD |
04592
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IMGT |
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EMBL |
AF076612
AF136632
AF136633
AF136634
AF136635
AF209928
AF209929
AF209930
AF283325
AY358926
BC112345
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GenPept |
AAC69835
AAF70236
AAF70237
AAF70238
AAF70239
AAG35767
AAG35768
AAG35769
AAG35784
AAI12346
AAQ89285
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