InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K13

Summary

InnateDB Protein

IDBP-386250.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K13

Protein Name

mitogen-activated protein kinase kinase kinase 13

Synonyms

LZK; MEKK13; MLK;

Species

Homo sapiens

Ensembl Protein

ENSP00000409325

InnateDB Gene

IDBG-68473 (MAP3K13)

Protein Structure

UniProt Annotation

Function

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269PubMed:11726277, ECO:0000269PubMed:12492477, ECO:0000269PubMed:9353328}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9353328}. Membrane {ECO:0000269PubMed:9353328}; Peripheral membrane protein {ECO:0000269PubMed:9353328}.

Disease Associations

Tissue Specificity

Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269PubMed:9353328}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007254	JNK cascade
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0008385	IkappaB kinase complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017419 Mitogen-activated protein kinase kinase kinase, 12/13
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF038165

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References