InnateDB Protein
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IDBP-386255.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAP3K13
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Protein Name
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mitogen-activated protein kinase kinase kinase 13
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Synonyms
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LZK; MEKK13; MLK;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403561
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InnateDB Gene
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IDBG-68473 (MAP3K13)
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Protein Structure
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Function |
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269PubMed:11726277, ECO:0000269PubMed:12492477, ECO:0000269PubMed:9353328}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9353328}. Membrane {ECO:0000269PubMed:9353328}; Peripheral membrane protein {ECO:0000269PubMed:9353328}.
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Disease Associations |
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Tissue Specificity |
Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269PubMed:9353328}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43283
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PhosphoSite |
PhosphoSite-O43283
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TrEMBL |
C9JP65
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UniProt Splice Variant |
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Entrez Gene |
9175
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UniGene |
Hs.715977
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RefSeq |
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HUGO |
HGNC:6852
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OMIM |
604915
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CCDS |
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HPRD |
05372
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IMGT |
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EMBL |
AB001872
AC099661
AC128680
AC132516
AK296961
AK297646
AK302951
AK312714
BC031677
BC111726
CH471052
Z25428
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GenPept |
AAH31677
AAI11727
BAA24817
BAG35589
BAG59505
BAG60014
BAG64106
CAA80915
EAW78224
EAW78225
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