InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRA2B

Summary

InnateDB Protein

IDBP-386311.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRA2B

Protein Name

transformer 2 beta homolog (Drosophila)

Synonyms

Htra2-beta; PPP1R156; SFRS10; SRFS10; TRA2-BETA; TRAN2B;

Species

Homo sapiens

Ensembl Protein

ENSP00000416959

InnateDB Gene

IDBG-68708 (TRA2B)

Protein Structure

UniProt Annotation

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA. {ECO:0000269PubMed:12165565, ECO:0000269PubMed:12761049, ECO:0000269PubMed:15009664, ECO:0000269PubMed:9546399}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9212162, ECO:0000269PubMed:9546399}.

Disease Associations

Tissue Specificity

Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. {ECO:0000269PubMed:9790768}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.

Experimentally validated
Total	78 [view]
Protein-Protein	78 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0048026	positive regulation of mRNA splicing, via spliceosome