Version 5.4
Homo sapiens Gene: TRA2B
Summary
InnateDB Gene IDBG-68708.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRA2B
Gene Name transformer 2 beta homolog (Drosophila)
Synonyms Htra2-beta; PPP1R156; SFRS10; SRFS10; TRA2-BETA; TRAN2B
Species Homo sapiens
Ensembl Gene ENSG00000136527
Encoded Proteins
IDBP-68710
transformer 2 beta homolog (Drosophila)
IDBP-68712
transformer 2 beta homolog (Drosophila)
IDBP-68714
transformer 2 beta homolog (Drosophila)
IDBP-386311
transformer 2 beta homolog (Drosophila)
IDBP-386312
transformer 2 beta homolog (Drosophila)
IDBP-386321
transformer 2 beta homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:185915906-185938136
Strand Reverse strand
Band q27.2
Transcripts
ENST00000259043 ENSP00000259043
ENST00000382191 ENSP00000371626
ENST00000342294 ENSP00000343857
ENST00000453386 ENSP00000416959
ENST00000414862 ENSP00000406561
ENST00000456380 ENSP00000416887
ENST00000492417
ENST00000463328
ENST00000487615
ENST00000466832
ENST00000465245
ENST00000485530
ENST00000493864
ENST00000477939
ENST00000471134
ENST00000480461
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
Experimentally validated
Total 78 [view]
Protein-Protein 78 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0048026 positive regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022858
View Gene Order
ENSBTAG00000001697
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133257 Hs.533122 Hs.705706 Hs.718147
RefSeq NM_001243879 NM_004593 XM_005247703 XM_006713724
HUGO
OMIM
CCDS CCDS33905 CCDS58872
HPRD 04097
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca