InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AHSG

Summary

InnateDB Protein

IDBP-386389.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHSG

Protein Name

alpha-2-HS-glycoprotein

Synonyms

A2HS; AHS; FETUA; HSGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000393887

InnateDB Gene

IDBG-68916 (AHSG)

Protein Structure

UniProt Annotation

Function

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0019210	kinase inhibitor activity

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0006907	pinocytosis
GO:0006953	acute-phase response
GO:0010951	negative regulation of endopeptidase activity
GO:0030500	regulation of bone mineralization
GO:0030502	negative regulation of bone mineralization
GO:0042326	negative regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050727	regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis