Version 5.4
Homo sapiens Protein: PLXNA4
Summary
InnateDB Protein IDBP-386396.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNA4
Protein Name plexin A4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392772
InnateDB Gene IDBG-281690 (PLXNA4)
Protein Structure
UniProt Annotation
Function Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007411 axon guidance
GO:0045087 innate immune response (InnateDB)
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0002116 semaphorin receptor complex
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
PFAM PF01403
PRINTS
PIRSF
SMART SM00630
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCM2
PhosphoSite PhosphoSite-Q9HCM2
TrEMBL
UniProt Splice Variant
Entrez Gene 91584
UniGene Hs.601190
RefSeq NP_001099013
HUGO HGNC:9102
OMIM 604280
CCDS CCDS43647
HPRD 10901
IMGT
EMBL AB046770 AC009364 AC009365 AC009785 AC011625 AC018643 AC026239 AK095606 AK123428 AL137352 AL834504 AY358850 BC028744 CH236950 CH471070
GenPept AAH28744 AAQ89209 BAB13376 BAC04587 BAC85615 CAB70707 CAD39161 EAL24076 EAW83793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca