InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST6GAL1

Summary

InnateDB Protein

IDBP-386469.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST6GAL1

Protein Name

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

Synonyms

SIAT1; ST6GalI; ST6N;

Species

Homo sapiens

Ensembl Protein

ENSP00000389337

InnateDB Gene

IDBG-69200 (ST6GAL1)

Protein Structure

UniProt Annotation

Function

Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. {ECO:0000269PubMed:21081508, ECO:0000269PubMed:23999306}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0006054	N-acetylneuraminate metabolic process
GO:0006486	protein glycosylation
GO:0006959	humoral immune response
GO:0016266	O-glycan processing
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome