Version 5.4
Homo sapiens Gene: ST6GAL1
Summary
InnateDB Gene IDBG-69200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST6GAL1
Gene Name ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Synonyms SIAT1; ST6GalI; ST6N
Species Homo sapiens
Ensembl Gene ENSG00000073849
Encoded Proteins
IDBP-69202
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386458
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386459
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386461
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386462
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386464
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386465
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386466
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386467
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386468
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386469
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386470
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386471
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386472
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386474
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
IDBP-386476
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:186930485-187078553
Strand Forward strand
Band q27.3
Transcripts
ENST00000169298 ENSP00000169298
ENST00000455441 ENSP00000397273
ENST00000427315 ENSP00000412821
ENST00000457772 ENSP00000412221
ENST00000458216 ENSP00000400547
ENST00000430309 ENSP00000399525
ENST00000417392 ENSP00000407631
ENST00000438590 ENSP00000416163
ENST00000448408 ENSP00000390793
ENST00000440338 ENSP00000388928
ENST00000448044 ENSP00000389337
ENST00000416235 ENSP00000414504
ENST00000423451 ENSP00000411518
ENST00000446170 ENSP00000388789
ENST00000448449 ENSP00000415886
ENST00000442023 ENSP00000403063
ENST00000463542
ENST00000487031
ENST00000468614
ENST00000485105
ENST00000464827
ENST00000470633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0006054 N-acetylneuraminate metabolic process
GO:0006486 protein glycosylation
GO:0006959 humoral immune response
GO:0016266 O-glycan processing
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022885
View Gene Order
ENSBTAG00000010357
Not yet available
Pathways
NETPATH
REACTOME
REACT_25085
N-Glycan antennae elongation pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200727
O-linked glycosylation pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.207459
RefSeq NM_003032 NM_173216 NM_173217 XM_005247717 XM_005247719 XM_005247720 XM_006713734
HUGO
OMIM
CCDS CCDS3285 CCDS46973
HPRD 00184
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca