InnateDB Protein
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IDBP-386475.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RIF1
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Protein Name
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RAP1 interacting factor homolog (yeast)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414615
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InnateDB Gene
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IDBG-72137 (RIF1)
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Protein Structure
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Function |
Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. {ECO:0000269PubMed:15342490}.
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Subcellular Localization |
Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis. {ECO:0000269PubMed:15583028}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
37
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016024
Armadillo-type fold
IPR022031
Telomere-associated protein Rif1, N-terminal
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PFAM |
PF12231
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5UIP0
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PhosphoSite |
PhosphoSite-Q5UIP0
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TrEMBL |
C9J1D6
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UniProt Splice Variant |
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Entrez Gene |
55183
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UniGene |
Hs.735592
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RefSeq |
NP_001171134
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HUGO |
HGNC:23207
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OMIM |
608952
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CCDS |
CCDS54406
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HPRD |
10603
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IMGT |
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EMBL |
AC009311
AC009497
AK001461
AK022932
AK024033
AK074349
AK299291
AL080129
AY584066
AY585745
AY727910
AY727911
AY727912
AY727913
CR933663
U79263
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GenPept |
AAB50209
AAS94233
AAT40745
AAV51401
AAV51402
AAV51403
AAV51404
BAA91705
BAB14313
BAB14792
BAB85058
BAG61306
CAB45727
CAI45961
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