Version 5.4
Homo sapiens Protein: RIF1
Summary
InnateDB Protein IDBP-386477.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIF1
Protein Name RAP1 interacting factor homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000390181
InnateDB Gene IDBG-72137 (RIF1)
Protein Structure
UniProt Annotation
Function Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. {ECO:0000269PubMed:15342490}.
Subcellular Localization Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.
Disease Associations
Tissue Specificity Highly expressed in testis. {ECO:0000269PubMed:15583028}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
IPR022031 Telomere-associated protein Rif1, N-terminal
PFAM PF12231
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5UIP0
PhosphoSite PhosphoSite-Q5UIP0
TrEMBL C9J1D6
UniProt Splice Variant
Entrez Gene 55183
UniGene Hs.735592
RefSeq NP_060621
HUGO HGNC:23207
OMIM 608952
CCDS CCDS2194
HPRD 10603
IMGT
EMBL AC009311 AC009497 AK001461 AK022932 AK024033 AK074349 AK299291 AL080129 AY584066 AY585745 AY727910 AY727911 AY727912 AY727913 CR933663 U79263
GenPept AAB50209 AAS94233 AAT40745 AAV51401 AAV51402 AAV51403 AAV51404 BAA91705 BAB14313 BAB14792 BAB85058 BAG61306 CAB45727 CAI45961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca