Version 5.4
Homo sapiens Protein: CNOT4
Summary
InnateDB Protein IDBP-386565.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT4
Protein Name CCR4-NOT transcription complex, subunit 4
Synonyms CLONE243; NOT4; NOT4H;
Species Homo sapiens
Ensembl Protein ENSP00000406777
InnateDB Gene IDBG-42604 (CNOT4)
Protein Structure
UniProt Annotation
Function Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway. {ECO:0000269PubMed:11823428, ECO:0000269PubMed:22159038}.
Subcellular Localization Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 15 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051865 protein autoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030014 CCR4-NOT complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR001841 Zinc finger, RING-type
IPR003954 RNA recognition motif domain, eukaryote
PFAM PF00076
PF13639
PF14634
PRINTS
PIRSF
SMART SM00360
SM00184
SM00361
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95628
PhosphoSite PhosphoSite-O95628
TrEMBL A0A024R781
UniProt Splice Variant
Entrez Gene 4850
UniGene Hs.490224
RefSeq NP_001177776
HUGO HGNC:7880
OMIM 604911
CCDS CCDS55164
HPRD 05369
IMGT
EMBL AC074002 AC083871 AF091094 AF180475 AK074671 AK300365 AL389980 BC035590 CH471070 U71267 U71268
GenPept AAC72963 AAD00179 AAD00180 AAF29829 AAH35590 BAC11125 BAH13270 CAB97536 EAW83850 EAW83851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca