Homo sapiens Protein: CHRM2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-386607.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CHRM2 | ||||||||||||||||||
Protein Name | cholinergic receptor, muscarinic 2 | ||||||||||||||||||
Synonyms | HM2; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000399745 | ||||||||||||||||||
InnateDB Gene | IDBG-42882 (CHRM2) | ||||||||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||||||||
Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269PubMed:24256733, ECO:0000269PubMed:3443095}. | ||||||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. {ECO:0000269PubMed:15229186}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000995 Muscarinic acetylcholine receptor family IPR001065 Muscarinic acetylcholine receptor M2 IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00237
PR00243 PR00539 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P08172 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P08172 | ||||||||||||||||||
TrEMBL | Q96RH0 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1129 | ||||||||||||||||||
UniGene | Hs.743546 | ||||||||||||||||||
RefSeq | NP_001006631 | ||||||||||||||||||
HUGO | HGNC:1951 | ||||||||||||||||||
OMIM | 118493 | ||||||||||||||||||
CCDS | CCDS5843 | ||||||||||||||||||
HPRD | 00328 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB041391 AF385588 AF498916 AK290236 AY034603 AY034604 AY034605 AY219703 AY219704 AY219705 AY456128 AY456129 BC095547 BC106741 BC106742 CH236950 CH471070 M16404 X15264 | ||||||||||||||||||
GenPept | AAA51570 AAH95547 AAI06742 AAI06743 AAK68113 AAM18939 AAO23567 AAO23568 AAO23569 AAO65595 AAO65596 AAO65597 AAR14893 AAR14894 BAA94476 BAF82925 CAA33335 EAL24054 EAW83866 | ||||||||||||||||||