Homo sapiens Gene: CHRM2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-42882.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CHRM2 | ||||||||||||||||||
Gene Name | cholinergic receptor, muscarinic 2 | ||||||||||||||||||
Synonyms | HM2 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000181072 | ||||||||||||||||||
Encoded Proteins |
cholinergic receptor, muscarinic 2
cholinergic receptor, muscarinic 2
cholinergic receptor, muscarinic 2
cholinergic receptor, muscarinic 2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 7:136868669-137020255 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q33 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
G alpha (i) signalling events pathway
Muscarinic acetylcholine receptors pathway
Amine ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Neuroactive ligand-receptor interaction pathway
Calcium signaling pathway pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.535891 Hs.743546 | ||||||||||||||||||
RefSeq | NM_000739 NM_001006626 NM_001006627 NM_001006628 NM_001006629 NM_001006630 NM_001006631 NM_001006632 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS5843 | ||||||||||||||||||
HPRD | 00328 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||