InnateDB Protein
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IDBP-386615.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL1RAP
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Protein Name
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interleukin 1 receptor accessory protein
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Synonyms
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C3orf13; IL-1RAcP; IL1R3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409352
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InnateDB Gene
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IDBG-69682 (IL1RAP)
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Protein Structure
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Function |
Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269PubMed:10799889, ECO:0000269PubMed:12530978, ECO:0000269PubMed:9371760}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.
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Disease Associations |
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Tissue Specificity |
Detected in liver, skin, placenta, thymus and lung. {ECO:0000269PubMed:12530978}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR004074
Interleukin-1 receptor type I/II
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
PR01536
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NPH3
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PhosphoSite |
PhosphoSite-Q9NPH3
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TrEMBL |
C9JT28
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UniProt Splice Variant |
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Entrez Gene |
3556
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UniGene |
Hs.624644
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RefSeq |
NP_608273
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HUGO |
HGNC:5995
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OMIM |
602626
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CCDS |
CCDS46982
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HPRD |
04021
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IMGT |
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EMBL |
AB006537
AC008249
AC108747
AF016261
AF029213
AF167335
AF167336
AF167337
AF167338
AF167339
AF167340
AF167341
AF167342
AF167343
AF487335
AF538730
AF538731
AF538732
AF538733
AF538734
BC053621
CH471052
EF591790
FJ998418
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GenPept |
AAB84059
AAC39609
AAF71687
AAF71688
AAF71689
AAH53621
AAO49451
AAQ01755
AAQ01756
AAQ01757
AAQ01758
AAQ01759
ABU90811
ACR82488
BAA25421
EAW78100
EAW78102
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