Version 5.4
Homo sapiens Gene: IL1RAP
Summary
InnateDB Gene IDBG-69682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RAP
Gene Name interleukin 1 receptor accessory protein
Synonyms C3orf13; IL-1RAcP; IL1R3
Species Homo sapiens
Ensembl Gene ENSG00000196083
Encoded Proteins
IDBP-69684
interleukin 1 receptor accessory protein
IDBP-69686
interleukin 1 receptor accessory protein
IDBP-69688
interleukin 1 receptor accessory protein
IDBP-386612
interleukin 1 receptor accessory protein
IDBP-386613
interleukin 1 receptor accessory protein
IDBP-386614
interleukin 1 receptor accessory protein
IDBP-386615
interleukin 1 receptor accessory protein
IDBP-386617
interleukin 1 receptor accessory protein
IDBP-386618
interleukin 1 receptor accessory protein
IDBP-386619
interleukin 1 receptor accessory protein
IDBP-386620
interleukin 1 receptor accessory protein
IDBP-386622
interleukin 1 receptor accessory protein
IDBP-386623
interleukin 1 receptor accessory protein
IDBP-386626
interleukin 1 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22426547
IL1RAP is recruited to the IL1B::IL1R1 ligand-receptor complex to initiate the IL1B signalling cascade.
InnateDB Annotation from Orthologs
Summary
PMID 22426547
[Mus musculus] Il1rap is recruited to the Il1b::Il1r1 ligand-receptor complex to initiate the Il1b signalling cascade. (Demonstrated in human)
Entrez Gene
Summary Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:190514051-190659750
Strand Forward strand
Band q28
Transcripts
ENST00000072516 ENSP00000072516
ENST00000342550 ENSP00000345829
ENST00000317757 ENSP00000314807
ENST00000447382 ENSP00000390541
ENST00000439062 ENSP00000401132
ENST00000422625 ENSP00000389149
ENST00000422485 ENSP00000409352
ENST00000443369 ENSP00000408893
ENST00000412504 ENSP00000412053
ENST00000413869 ENSP00000416296
ENST00000422940 ENSP00000387371
ENST00000434491 ENSP00000391899
ENST00000453359 ENSP00000412008
ENST00000412080 ENSP00000414102
ENST00000465496
ENST00000461629
ENST00000473566
ENST00000476929
ENST00000482913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0042094 interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022514
View Gene Order
ENSBTAG00000013205
Not yet available
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
KEGG
hsa04210
Apoptosis pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
JAK STAT pathway and regulation pathway
PID NCI
il1pathway
IL1-mediated signaling events
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478673 Hs.624644
RefSeq NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470 XM_005247433 XM_005247434
HUGO
OMIM
CCDS CCDS3298 CCDS46982 CCDS54696
HPRD 04021
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca