InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RAP

Summary

InnateDB Protein

IDBP-386619.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RAP

Protein Name

interleukin 1 receptor accessory protein

Synonyms

C3orf13; IL-1RAcP; IL1R3;

Species

Homo sapiens

Ensembl Protein

ENSP00000416296

InnateDB Gene

IDBG-69682 (IL1RAP)

Protein Structure

UniProt Annotation

Function

Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269PubMed:10799889, ECO:0000269PubMed:12530978, ECO:0000269PubMed:9371760}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Detected in liver, skin, placenta, thymus and lung. {ECO:0000269PubMed:12530978}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin

PFAM

PF00047

PRINTS

PR01536

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NPH3

PhosphoSite

PhosphoSite-Q9NPH3

TrEMBL

C9JT28

UniProt Splice Variant

Entrez Gene

3556

UniGene

Hs.624644

RefSeq

HUGO

HGNC:5995

OMIM

602626

CCDS

HPRD

04021

IMGT

EMBL

AB006537 AC008249 AC108747 AF016261 AF029213 AF167335 AF167336 AF167337 AF167338 AF167339 AF167340 AF167341 AF167342 AF167343 AF487335 AF538730 AF538731 AF538732 AF538733 AF538734 BC053621 CH471052 EF591790 FJ998418

GenPept

AAB84059 AAC39609 AAF71687 AAF71688 AAF71689 AAH53621 AAO49451 AAQ01755 AAQ01756 AAQ01757 AAQ01758 AAQ01759 ABU90811 ACR82488 BAA25421 EAW78100 EAW78102