InnateDB Protein
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IDBP-386648.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CREB3L2
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Protein Name
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cAMP responsive element binding protein 3-like 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403550
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InnateDB Gene
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IDBG-43070 (CREB3L2)
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Protein Structure
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Function |
Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:17178827}; Single-pass type II membrane protein {ECO:0000269PubMed:17178827}.Processed cyclic AMP-responsive element- binding protein 3-like protein 2: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
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Disease Associations |
Note=A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.
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Tissue Specificity |
Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. {ECO:0000269PubMed:12915480}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q70SY1
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PhosphoSite |
PhosphoSite-Q70SY1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64764
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UniGene |
Hs.742108
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RefSeq |
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HUGO |
HGNC:23720
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OMIM |
608834
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CCDS |
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HPRD |
16391
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IMGT |
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EMBL |
AJ549092
AJ549387
AK131517
BC063666
BC110813
CH236950
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GenPept |
AAH63666
AAI10814
BAD18659
CAD79342
CAD79347
EAL24050
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