InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CREB3L2

Summary

InnateDB Gene

IDBG-43070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB3L2

Gene Name

cAMP responsive element binding protein 3-like 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182158

Encoded Proteins

IDBP-43072

cAMP responsive element binding protein 3-like 2

IDBP-386648

cAMP responsive element binding protein 3-like 2

IDBP-386649

cAMP responsive element binding protein 3-like 2

IDBP-386650

cAMP responsive element binding protein 3-like 2

IDBP-386652

cAMP responsive element binding protein 3-like 2

IDBP-808620

cAMP responsive element binding protein 3-like 2

IDBP-808624

cAMP responsive element binding protein 3-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:137874979-138002067

Strand

Reverse strand

Band

q33

Transcripts

ENST00000330387	ENSP00000329140
ENST00000456390	ENSP00000403550
ENST00000452463	ENSP00000410314
ENST00000458726	ENSP00000388917
ENST00000420629	ENSP00000402889
ENST00000468127
ENST00000620715	ENSP00000478809
ENST00000616381	ENSP00000478432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006986	response to unfolded protein
GO:0034976	response to endoplasmic reticulum stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038648

View Gene Order

ENSBTAG00000015802

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05215

Prostate cancer pathway

hsa04916

Melanogenesis pathway

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q70SY1

TrEMBL

UniProt Splice Variant

Entrez Gene

64764

UniGene

Hs.724212 Hs.742108

RefSeq

NM_194071 XM_005250541 NM_001253775

HUGO

HGNC:23720

OMIM

608834

CCDS

CCDS34760 CCDS59083

HPRD

16391

IMGT

EMBL

AJ549092 AJ549387 AK131517 BC063666 BC110813 CH236950

GenPept

AAH63666 AAI10814 BAD18659 CAD79342 CAD79347 EAL24050

RNA Seq Atlas

64764