InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREB3L2

Summary

InnateDB Protein

IDBP-386649.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREB3L2

Protein Name

cAMP responsive element binding protein 3-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410314

InnateDB Gene

IDBG-43070 (CREB3L2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:17178827}; Single-pass type II membrane protein {ECO:0000269PubMed:17178827}.Processed cyclic AMP-responsive element- binding protein 3-like protein 2: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Disease Associations

Note=A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.

Tissue Specificity

Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. {ECO:0000269PubMed:12915480}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0034976	response to endoplasmic reticulum stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051216	cartilage development