Version 5.4
Homo sapiens Protein: MUC20
Summary
InnateDB Protein IDBP-386865.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC20
Protein Name mucin 20, cell surface associated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000405629
InnateDB Gene IDBG-70656 (MUC20)
Protein Structure
UniProt Annotation
Function May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. {ECO:0000269PubMed:15314156}.
Subcellular Localization Secreted {ECO:0000305}. Apical cell membrane {ECO:0000269PubMed:14565953}. Basolateral cell membrane {ECO:0000269PubMed:14565953}. Cell projection, microvillus membrane {ECO:0000269PubMed:14565953}.
Disease Associations
Tissue Specificity Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis. {ECO:0000269PubMed:14565953, ECO:0000269PubMed:16997931}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0009925 basal plasma membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N307
PhosphoSite PhosphoSite-Q8N307
TrEMBL I0EZ60
UniProt Splice Variant
Entrez Gene 200958
UniGene Hs.739367
RefSeq
HUGO HGNC:23282
OMIM 610360
CCDS
HPRD 17615
IMGT
EMBL AB037780 AB098731 AB098733 AC069513 AK027314 AK075138 AY358449 BC029267 BC044243 JQ411644 JQ411645 JQ582411 JQ582415
GenPept AAH29267 AAH44243 AAQ88814 AFH78580 AFH78584 AFI24895 AFI24896 BAA92597 BAB55035 BAC11428 BAD06718 BAD06720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca