InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LOX

Summary

InnateDB Protein

IDBP-38694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOX

Protein Name

lysyl oxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000231004

InnateDB Gene

IDBG-38692 (LOX)

Protein Structure

UniProt Annotation

Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas. {ECO:0000269PubMed:7706256}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001568	blood vessel development
GO:0006464	cellular protein modification process
GO:0009725	response to hormone
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0048251	elastic fiber assembly
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process