InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LOX

Summary

InnateDB Gene

IDBG-38692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOX

Gene Name

lysyl oxidase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000113083

Encoded Proteins

IDBP-38694

lysyl oxidase

IDBP-482247

lysyl oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:122063195-122078285

Strand

Reverse strand

Band

q23.1

Transcripts

ENST00000231004	ENSP00000231004
ENST00000513319
ENST00000505593
ENST00000503759
ENST00000508067	ENSP00000427538

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001568	blood vessel development
GO:0006464	cellular protein modification process
GO:0009725	response to hormone
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0048251	elastic fiber assembly
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024529

View Gene Order

ENSBTAG00000012994

Not yet available

Pathways

NETPATH

REACTOME

REACT_150206

Crosslinking of collagen fibrils pathway

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YAL3

UniProt Splice Variant

Entrez Gene

4015

UniGene

Hs.102267 Hs.660104 Hs.670905 Hs.696708 Hs.708303 Hs.726711

RefSeq

NM_001178102 NM_002317

HUGO

HGNC:6664

OMIM

153455

CCDS

CCDS4129

HPRD

01087

IMGT

EMBL

AC010255

GenPept

RNA Seq Atlas

4015