Version 5.4
Homo sapiens Protein: SLC4A10
Summary
InnateDB Protein IDBP-386984.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC4A10
Protein Name solute carrier family 4, sodium bicarbonate transporter, member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000395797
InnateDB Gene IDBG-73631 (SLC4A10)
Protein Structure
UniProt Annotation
Function Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0015701 bicarbonate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003020 Bicarbonate transporter, eukaryotic
IPR003024 Sodium bicarbonate cotransporter
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter
PFAM PF00955
PF07565
PRINTS PR01231
PR01232
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6U841
PhosphoSite PhosphoSite-Q6U841
TrEMBL
UniProt Splice Variant
Entrez Gene 57282
UniGene Hs.623881
RefSeq NP_071341
HUGO HGNC:13811
OMIM 605556
CCDS CCDS46438
HPRD
IMGT
EMBL AB040457 AC008063 AC009487 AC062022 AC092654 AC092841 AC096654 AK293793 AK294767 AL713680 AL832525 AY376402 BC136269 BC143714 CH471058
GenPept AAI36270 AAI43715 AAQ83632 AAX88962 BAB18301 BAH11596 BAH11876 CAD28484 CAD38630 EAX11364

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca