InnateDB Protein
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IDBP-387147.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIGZ
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Protein Name
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phosphatidylinositol glycan anchor biosynthesis, class Z
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000413405
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InnateDB Gene
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IDBG-71431 (PIGZ)
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Protein Structure
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Function |
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. {ECO:0000269PubMed:15208306}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:15208306}; Multi-pass membrane protein {ECO:0000269PubMed:15208306}.
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Disease Associations |
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Tissue Specificity |
Widely expressed at low level, with highest level in brain and colon. {ECO:0000269PubMed:15208306}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0000026
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alpha-1,2-mannosyltransferase activity
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GO:0000030
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mannosyltransferase activity
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GO:0016757
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transferase activity, transferring glycosyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005599
GPI mannosyltransferase
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PFAM |
PF03901
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VD9
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PhosphoSite |
PhosphoSite-Q86VD9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80235
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UniGene |
Hs.518403
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RefSeq |
NP_079439
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HUGO |
HGNC:30596
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OMIM |
611671
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CCDS |
CCDS3324
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HPRD |
18076
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IMGT |
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EMBL |
AC011322
AK022830
BC044640
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GenPept |
AAH44640
BAB14263
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