Homo sapiens Gene: PIGZ
Summary
InnateDB Gene IDBG-71431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGZ
Gene Name phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119227
Encoded Proteins
phosphatidylinositol glycan anchor biosynthesis, class Z
phosphatidylinositol glycan anchor biosynthesis, class Z
phosphatidylinositol glycan anchor biosynthesis, class Z
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:196946343-196969060
Strand Reverse strand
Band q29
Transcripts
ENST00000238138
ENST00000412723 ENSP00000413405
ENST00000413127 ENSP00000405341
ENST00000443835 ENSP00000389327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000026 alpha-1,2-mannosyltransferase activity
GO:0000030 mannosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0008152 metabolic process
GO:0097502 mannosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518403
RefSeq NM_025163 XM_006713758
HUGO
OMIM
CCDS CCDS3324
HPRD 18076
IMGT
EMBL
GenPept
RNA Seq Atlas