InnateDB Protein
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IDBP-38725.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANGPT4
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Protein Name
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angiopoietin 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371347
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InnateDB Gene
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IDBG-38723 (ANGPT4)
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Protein Structure
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Function |
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. {ECO:0000269PubMed:15284220}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the lung with much lower levels found in other tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0030297
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transmembrane receptor protein tyrosine kinase activator activity
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GO:0030971
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receptor tyrosine kinase binding
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Biological Process |
GO:0001525
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angiogenesis
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GO:0007171
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activation of transmembrane receptor protein tyrosine kinase activity
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GO:0007596
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blood coagulation
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GO:0010595
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positive regulation of endothelial cell migration
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GO:0016525
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negative regulation of angiogenesis
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GO:0043066
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negative regulation of apoptotic process
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GO:0043536
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positive regulation of blood vessel endothelial cell migration
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GO:0043537
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negative regulation of blood vessel endothelial cell migration
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GO:0045766
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positive regulation of angiogenesis
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0050900
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leukocyte migration
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GO:0071456
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cellular response to hypoxia
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
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PFAM |
PF00147
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y264
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PhosphoSite |
PhosphoSite-Q9Y264
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51378
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UniGene |
Hs.278973
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RefSeq |
NP_057069
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HUGO |
HGNC:487
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OMIM |
603705
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CCDS |
CCDS13009
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HPRD |
04747
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IMGT |
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EMBL |
AF074332
AF113708
AK304756
AL050325
AL161939
BC111976
BC111978
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GenPept |
AAD21587
AAD31728
AAI11977
AAI11979
BAG65511
CAC09933
CAI22922
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