InnateDB Protein
|
IDBP-387374.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CLEC12A
|
Protein Name
|
C-type lectin domain family 12, member A
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000405244
|
InnateDB Gene
|
IDBG-18239 (CLEC12A)
|
Protein Structure
|
|
Function |
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269PubMed:14739280, ECO:0000269PubMed:16239426}.
|
Subcellular Localization |
Cell membrane {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}; Single-pass type II membrane protein {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}. Note=Ligand binding leads to internalization.
|
Disease Associations |
|
Tissue Specificity |
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. {ECO:0000269PubMed:14739280, ECO:0000269PubMed:15548716, ECO:0000269PubMed:16239426, ECO:0000269PubMed:16838277}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001304
C-type lectin
IPR016187
C-type lectin fold
|
PFAM |
PF00059
|
PRINTS |
|
PIRSF |
|
SMART |
SM00034
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5QGZ9
|
PhosphoSite |
PhosphoSite-Q5QGZ9
|
TrEMBL |
A8MVL9
|
UniProt Splice Variant |
|
Entrez Gene |
160364
|
UniGene |
Hs.190519
|
RefSeq |
NP_001287659
|
HUGO |
HGNC:31713
|
OMIM |
612088
|
CCDS |
CCDS73442
|
HPRD |
14719
|
IMGT |
|
EMBL |
AC091814
AF247788
AK314001
AY426759
AY498550
AY498551
AY498552
AY547296
BC063424
BC126289
BC126291
CH471094
|
GenPept |
AAH63424
AAI26290
AAI26292
AAL95693
AAR84594
AAS00605
AAS00606
AAS00607
AAT11783
BAG36713
EAW96133
|
|
|