InnateDB Protein
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IDBP-387451.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAP7
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Protein Name
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microtubule-associated protein 7
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Synonyms
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E-MAP-115; EMAP115;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000414879
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InnateDB Gene
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IDBG-96924 (MAP7)
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Protein Structure
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Function |
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. {ECO:0000269PubMed:11719555, ECO:0000269PubMed:8408219, ECO:0000269PubMed:9989799}.
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Subcellular Localization |
Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
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Disease Associations |
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Tissue Specificity |
Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. {ECO:0000269PubMed:8408219, ECO:0000269PubMed:9989799}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008604
Microtubule-associated protein 7
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PFAM |
PF05672
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14244
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PhosphoSite |
PhosphoSite-Q14244
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9053
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UniGene |
Hs.486548
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RefSeq |
NP_001185548
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HUGO |
HGNC:6869
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OMIM |
604108
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CCDS |
CCDS56452
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HPRD |
04982
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IMGT |
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EMBL |
AJ242501
AJ242502
AK294461
AK296556
AK299355
AK316062
AL023284
AL024508
AL133511
BC025777
X73882
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GenPept |
AAH25777
BAH11776
BAH12386
BAH13013
BAH14433
CAA52086
CAB88030
CAB88031
CAD92557
CAI20475
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