Version 5.4
Homo sapiens Gene: MAP7
Summary
InnateDB Gene IDBG-96924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP7
Gene Name microtubule-associated protein 7
Synonyms E-MAP-115; EMAP115
Species Homo sapiens
Ensembl Gene ENSG00000135525
Encoded Proteins
IDBP-96926
microtubule-associated protein 7
IDBP-387448
microtubule-associated protein 7
IDBP-387450
microtubule-associated protein 7
IDBP-387451
microtubule-associated protein 7
IDBP-586934
microtubule-associated protein 7
IDBP-806855
microtubule-associated protein 7
IDBP-806857
microtubule-associated protein 7
IDBP-806858
microtubule-associated protein 7
IDBP-806859
microtubule-associated protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:136342281-136550819
Strand Reverse strand
Band q23.3
Transcripts
ENST00000354570 ENSP00000346581
ENST00000454590 ENSP00000414712
ENST00000438100 ENSP00000400790
ENST00000432797 ENSP00000414879
ENST00000544465 ENSP00000445737
ENST00000611373 ENSP00000482998
ENST00000618822 ENSP00000482356
ENST00000617204 ENSP00000482335
ENST00000616617 ENSP00000483511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000902 cell morphogenesis
GO:0001578 microtubule bundle formation
GO:0006687 glycosphingolipid metabolic process
GO:0006970 response to osmotic stress
GO:0006997 nucleus organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0009566 fertilization
GO:0032526 response to retinoic acid
GO:0033327 Leydig cell differentiation
GO:0035265 organ growth
GO:0048872 homeostasis of number of cells
GO:0060009 Sertoli cell development
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0016323 basolateral plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019996
View Gene Order
ENSBTAG00000001598
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001198608 NM_001198609 NM_001198611 NM_001198614 NM_001198615 NM_001198616 NM_001198617 NM_001198618 NM_001198619 NM_003980 XM_005267209 XM_006715598 XM_006715599 XM_006715600
HUGO
OMIM
CCDS CCDS5178 CCDS56452 CCDS56453 CCDS56454 CCDS56455 CCDS75527 CCDS75528 CCDS75529
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca