InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX17

Summary

InnateDB Protein

IDBP-38756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX17

Protein Name

sorting nexin 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233575

InnateDB Gene

IDBG-38752 (SNX17)

Protein Structure

UniProt Annotation

Function

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). {ECO:0000269PubMed:15121882, ECO:0000269PubMed:15769472, ECO:0000269PubMed:16712798, ECO:0000269PubMed:19005208, ECO:0000269PubMed:21512128, ECO:0000269PubMed:22492727}.

Subcellular Localization

Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0035091	phosphatidylinositol binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0006707	cholesterol catabolic process
GO:0006886	intracellular protein transport
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0016197	endosomal transport
GO:0030100	regulation of endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex