InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNX17

Summary

InnateDB Gene

IDBG-38752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX17

Gene Name

sorting nexin 17

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115234

Encoded Proteins

IDBP-38756

sorting nexin 17

IDBP-369476

sorting nexin 17

IDBP-369478

sorting nexin 17

IDBP-369486

sorting nexin 17

IDBP-596873

sorting nexin 17

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:27370496-27377533

Strand

Forward strand

Band

p23.3

Transcripts

ENST00000233575	ENSP00000233575
ENST00000440760	ENSP00000399727
ENST00000427123	ENSP00000405399
ENST00000453453	ENSP00000401922
ENST00000484886
ENST00000494893
ENST00000464279
ENST00000489402
ENST00000493711
ENST00000537606	ENSP00000439208

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0035091	phosphatidylinositol binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0006707	cholesterol catabolic process
GO:0006886	intracellular protein transport
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0016197	endosomal transport
GO:0030100	regulation of endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029146

View Gene Order

ENSBTAG00000019515

Not yet available

Cross-References

SwissProt

Q15036

TrEMBL

B4DDM3 B4DLL7

UniProt Splice Variant

Entrez Gene

9784

UniGene

RefSeq

NM_001267060 NM_001267059 NM_001267061 NM_014748

HUGO

HGNC:14979

OMIM

605963

CCDS

CCDS58704 CCDS1750

HPRD

05812

IMGT

EMBL

AC074117 AJ404855 AJ404856 AK222543 AK293252 AK295278 AK297054 AK298856 AK298869 BC002524 BC002610 BC014620 BC050590 BT007167 CH471053 CR457081 D31764

GenPept

AAH02524 AAH02610 AAH14620 AAH50590 AAP35831 AAY14844 BAA06542 BAD96263 BAG56784 BAG58262 BAG59579 BAG60979 BAG60989 CAC12897 CAG33362 EAX00584

RNA Seq Atlas

9784