InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSTM2

Summary

InnateDB Protein

IDBP-387563.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM2

Protein Name

glutathione S-transferase mu 2 (muscle)

Synonyms

GST4; GSTM; GSTM2-2; GTHMUS;

Species

Homo sapiens

Ensembl Protein

ENSP00000416883

InnateDB Gene

IDBG-243147 (GSTM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0018916	nitrobenzene metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:0055119	relaxation of cardiac muscle
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0070458	cellular detoxification of nitrogen compound
GO:0071313	cellular response to caffeine
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016529	sarcoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003081 Glutathione S-transferase, Mu class
IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM