InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA7

Summary

InnateDB Protein

IDBP-38764.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA7

Protein Name

integrin, alpha 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257879

InnateDB Gene

IDBG-38762 (ITGA7)

Protein Structure

UniProt Annotation

Function

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269PubMed:10694445, ECO:0000269PubMed:17641293, ECO:0000269PubMed:9307969}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI) [MIM:613204]: A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. {ECO:0000269PubMed:9590299}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle. {ECO:0000269PubMed:8626012}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007517	muscle organ development
GO:0008360	regulation of cell shape
GO:0030198	extracellular matrix organization