InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN22

Summary

InnateDB Protein

IDBP-387810.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN22

Protein Name

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000388229

InnateDB Gene

IDBG-101222 (PTPN22)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0050856	regulation of T cell receptor signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR016276 Non-receptor tyrosine-protein phosphatase, 8/22
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000930

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References