InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNCAIP

Summary

InnateDB Protein

IDBP-38782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNCAIP

Protein Name

synuclein, alpha interacting protein

Synonyms

Sph1; SYPH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261368

InnateDB Gene

IDBG-38780 (SNCAIP)

Protein Structure

UniProt Annotation

Function

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269PubMed:16595633, ECO:0000269PubMed:19224863}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10319874, ECO:0000269PubMed:15064394, ECO:0000269PubMed:16595633, ECO:0000269PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.

Disease Associations

Parkinson disease (PARK) [MIM:168600]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features. {ECO:0000269PubMed:12761037}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. {ECO:0000269PubMed:10319874, ECO:0000269PubMed:16595633}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding

Biological Process

GO:0008219	cell death
GO:0042417	dopamine metabolic process
GO:0046928	regulation of neurotransmitter secretion
GO:0090083	regulation of inclusion body assembly