Version 5.4
Homo sapiens Protein: ESR1
Summary
InnateDB Protein IDBP-387827.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESR1
Protein Name estrogen receptor 1
Synonyms ER; Era; ESR; ESRA; ESTRR; NR3A1;
Species Homo sapiens
Ensembl Protein ENSP00000411105
InnateDB Gene IDBG-97997 (ESR1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 764 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 764 [view]
Protein-Protein 728 [view]
Protein-DNA 27 [view]
Protein-RNA 1 [view]
DNA-DNA 8 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005496 steroid binding
GO:0030284 estrogen receptor activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0043401 steroid hormone mediated signaling pathway
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001292 Oestrogen receptor
PFAM PF02159
PRINTS PR00543
PIRSF PIRSF500101
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9UE35
UniProt Splice Variant
Entrez Gene 2099
UniGene Hs.630134
RefSeq
HUGO HGNC:3467
OMIM 133430
CCDS
HPRD 00589
IMGT
EMBL AB685816 AL035695 AL049821 AL078582 AL356311 AL590993 JX524780 JX524781 JX996117 U68067 U68068 X62462
GenPept AAC51874 AAC51875 AFV77693 AFV77694 AGC74339 BAM62932 CAA44322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca