InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE1A

Summary

InnateDB Protein

IDBP-387897.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1A

Protein Name

phosphodiesterase 1A, calmodulin-dependent

Synonyms

CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000410309

InnateDB Gene

IDBG-76818 (PDE1A)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Subcellular Localization

Disease Associations

Tissue Specificity

Several tissues, including brain, kidney, testes and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0045087	innate immune response
GO:0046069	cGMP catabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048660	regulation of smooth muscle cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR000237 GRIP
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF01465
PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00755
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt