InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE1A

Summary

InnateDB Gene

IDBG-76818.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1A

Gene Name

phosphodiesterase 1A, calmodulin-dependent

Synonyms

CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A

Species

Homo sapiens

Ensembl Gene

ENSG00000115252

Encoded Proteins

IDBP-76822

phosphodiesterase 1A, calmodulin-dependent

IDBP-76824

phosphodiesterase 1A, calmodulin-dependent

IDBP-293367

phosphodiesterase 1A, calmodulin-dependent

IDBP-293369

phosphodiesterase 1A, calmodulin-dependent

IDBP-387897

phosphodiesterase 1A, calmodulin-dependent

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:182140036-182523192

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000358139	ENSP00000350858
ENST00000351439	ENSP00000309269
ENST00000409365	ENSP00000386767
ENST00000410103	ENSP00000387037
ENST00000435564	ENSP00000410309
ENST00000482538
ENST00000462938
ENST00000495511
ENST00000482782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034391	regulation of smooth muscle cell apoptotic process
GO:0045087	innate immune response
GO:0046069	cGMP catabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048660	regulation of smooth muscle cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059173

View Gene Order

ENSBTAG00000012100

Not yet available

Pathways

NETPATH

REACTOME

REACT_15408

Cam-PDE 1 activation pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_23767

cGMP effects pathway

REACT_23862

Nitric oxide stimulates guanylate cyclase pathway

REACT_23876

Platelet homeostasis pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_15307

Ca-dependent events pathway

REACT_116125

Disease pathway

REACT_604

Hemostasis pathway

KEGG

hsa00230

Purine metabolism pathway

hsa04742

Taste transduction pathway

hsa04020

Calcium signaling pathway pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.191046 Hs.742065

RefSeq

NM_001003683 NM_001258312 NM_001258313 NM_001258314 NM_005019 XM_005246636 XM_005246637 XM_006712574 XM_006712575 XM_006712576 XM_006712578 XM_006712579

HUGO

OMIM

CCDS

CCDS2285 CCDS33344 CCDS58741 CCDS74612

HPRD

01387

IMGT

EMBL

GenPept

RNA Seq Atlas