Homo sapiens Protein: COMP | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-38818.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | COMP | ||||||||||||||||||
Protein Name | cartilage oligomeric matrix protein | ||||||||||||||||||
Synonyms | EDM1; EPD1; MED; PSACH; THBS5; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000222271 | ||||||||||||||||||
InnateDB Gene | IDBG-38816 (COMP) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Secreted, extracellular space, extracellular matrix. | ||||||||||||||||||
Disease Associations | Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. {ECO:0000269PubMed:11565064, ECO:0000269PubMed:21922596, ECO:0000269PubMed:7670472, ECO:0000269PubMed:9021009, ECO:0000269PubMed:9184241, ECO:0000269PubMed:9452026, ECO:0000269PubMed:9463320, ECO:0000269PubMed:9921895}. Note=The disease is caused by mutations affecting the gene represented in this entry.Pseudoachondroplasia (PSACH) [MIM:177170]: A skeletal dysplasia usually manifesting in the second year of life and characterized by moderate to severe disproportionate short stature, deformity of the lower limbs, brachydactyly, ligamentous laxity, and degenerative joint disease. {ECO:0000269PubMed:11746044, ECO:0000269PubMed:11746045, ECO:0000269PubMed:21922596, ECO:0000269PubMed:7670471, ECO:0000269PubMed:7670472, ECO:0000269PubMed:9184241, ECO:0000269PubMed:9452026, ECO:0000269PubMed:9452063, ECO:0000269PubMed:9463320}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. {ECO:0000269PubMed:16542502}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000742
Epidermal growth factor-like domain IPR001881 EGF-like calcium-binding domain IPR003367 Thrombospondin, type 3-like repeat IPR008859 Thrombospondin, C-terminal IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain IPR028974 TSP type-3 repeat |
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PFAM |
PF00008
PF07645 PF02412 PF05735 PF11598 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00181
SM00179 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P49747 | ||||||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||||||
TrEMBL | G3XAP6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1311 | ||||||||||||||||||
UniGene | Hs.1584 | ||||||||||||||||||
RefSeq | NP_000086 | ||||||||||||||||||
HUGO | HGNC:2227 | ||||||||||||||||||
OMIM | 600310 | ||||||||||||||||||
CCDS | CCDS12385 | ||||||||||||||||||
HPRD | 02632 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB086984 AC003107 BC110847 BC125092 CH471106 L32137 S79499 S79500 | ||||||||||||||||||
GenPept | AAA57253 AAB35269 AAB35270 AAB86501 AAI10848 AAI25093 BAC53888 EAW84736 EAW84737 | ||||||||||||||||||