InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COMP

Summary

InnateDB Gene

IDBG-38816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COMP

Gene Name

cartilage oligomeric matrix protein

Synonyms

EDM1; EPD1; MED; PSACH; THBS5

Species

Homo sapiens

Ensembl Gene

ENSG00000105664

Encoded Proteins

IDBP-38818

cartilage oligomeric matrix protein

IDBP-376143

cartilage oligomeric matrix protein

IDBP-597186

cartilage oligomeric matrix protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18782773-18791314

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000222271	ENSP00000222271
ENST00000425807	ENSP00000403792
ENST00000542601	ENSP00000439156
ENST00000612179

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005201	extracellular matrix structural constituent
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0001501	skeletal system development
GO:0003417	growth plate cartilage development
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0009887	organ morphogenesis
GO:0030198	extracellular matrix organization
GO:0043066	negative regulation of apoptotic process
GO:0060173	limb development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031849

View Gene Order

ENSBTAG00000004630

Not yet available

Pathways

NETPATH

REACTOME

REACT_13552

Integrin cell surface interactions pathway

REACT_118779

Extracellular matrix organization pathway

REACT_163906

ECM proteoglycans pathway

KEGG

hsa04512

ECM-receptor interaction pathway

hsa04510

Focal adhesion pathway

hsa05144

Malaria pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P49747

TrEMBL

B4DKJ3 G3XAP6

UniProt Splice Variant

Entrez Gene

1311

UniGene

Hs.1584

RefSeq

NM_000095

HUGO

HGNC:2227

OMIM

600310

CCDS

CCDS12385

HPRD

IMGT

EMBL

AB086984 AC003107 AK296586 BC110847 BC125092 CH471106 L32137 S79499 S79500

GenPept

AAA57253 AAB35269 AAB35270 AAB86501 AAI10848 AAI25093 BAC53888 BAG59205 EAW84736 EAW84737

RNA Seq Atlas

1311