InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCL1

Summary

InnateDB Protein

IDBP-388198.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCL1

Protein Name

phospholipase C-like 1

Synonyms

PLCE; PLCL; PLDL1; PPP1R127; PRIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000402861

InnateDB Gene

IDBG-78092 (PLCL1)

Protein Structure

UniProt Annotation

Function

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. {ECO:0000250, ECO:0000269PubMed:17254016}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269PubMed:16952428, ECO:0000269PubMed:7633416}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0050811	GABA receptor binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0033135	regulation of peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:1900122	positive regulation of receptor binding

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF00169
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt