InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LANCL1

Summary

InnateDB Protein

IDBP-388704.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LANCL1

Protein Name

LanC lantibiotic synthetase component C-like 1 (bacterial)

Synonyms

GPR69A; p40;

Species

Homo sapiens

Ensembl Protein

ENSP00000393323

InnateDB Gene

IDBG-79963 (LANCL1)

Protein Structure

UniProt Annotation

Function

May play a role in EPS8 signaling. Binds glutathione. {ECO:0000269PubMed:19528316}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Detected at the surface of Maurer's clefts in malaria-infected erythrocytes at late stages of parasite development.

Disease Associations

Tissue Specificity

Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis. {ECO:0000269PubMed:10944443, ECO:0000269PubMed:15811525, ECO:0000269PubMed:9512664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0043295	glutathione binding
GO:0050750	low-density lipoprotein particle receptor binding