Version 5.4
Homo sapiens Gene: LANCL1
Summary
InnateDB Gene IDBG-79963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LANCL1
Gene Name LanC lantibiotic synthetase component C-like 1 (bacterial)
Synonyms GPR69A; p40
Species Homo sapiens
Ensembl Gene ENSG00000115365
Encoded Proteins
IDBP-79965
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388700
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388701
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388702
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388704
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388706
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388707
LanC lantibiotic synthetase component C-like 1 (bacterial)
IDBP-388708
LanC lantibiotic synthetase component C-like 1 (bacterial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:210431249-210477652
Strand Reverse strand
Band q34
Transcripts
ENST00000233714 ENSP00000233714
ENST00000443314 ENSP00000388713
ENST00000431941 ENSP00000397646
ENST00000450366 ENSP00000393597
ENST00000441020 ENSP00000393323
ENST00000412863 ENSP00000405364
ENST00000448951 ENSP00000396518
ENST00000453956 ENSP00000395442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0043295 glutathione binding
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026000
View Gene Order
ENSBTAG00000015066
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13351 Hs.712663
RefSeq NM_001136574 NM_001136575 NM_006055 XM_005246243
HUGO
OMIM
CCDS CCDS2392
HPRD 16040
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca