InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INTS3

Summary

InnateDB Protein

IDBP-388712.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INTS3

Protein Name

integrator complex subunit 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000404290

InnateDB Gene

IDBG-102774 (INTS3)

Protein Structure

UniProt Annotation

Function

Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19605351, ECO:0000269PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007093	mitotic cell cycle checkpoint
GO:0010212	response to ionizing radiation
GO:0016180	snRNA processing